Lindsay Lohan as Cady Heron
Rachel McAdams as Regina George
Tina Fey as Ms. Sharon Norbury
Tim Meadows as Mr. Ron Duvall
Amy Poehler as Mrs. George
Ana Gasteyer as Mrs. Heron
Lacey Chabert as Gretchen Wieners
Amanda Seyfried as Karen Smith
Lizzy Caplan as Janis Ian
Daniel Franzese as Damian
Neil Flynn as Mr. Heron
Jonathan Bennett as Aaron Samuels